The review on biological activities of ent-kaurane diterpenoids extracted from crotontonkinensis
DOI:
https://doi.org/10.62685/tbjmp.2024.14.04Từ khóa:
Croton tonkinensis, ent-kaurane diterpenoids, anticancer, anti-inflammation, antibaterial effect.Tóm tắt
Objective: Croton tonkinensis has been a focal point of medicinal research due to its rich phytochemical composition, particularly ent-kaurane diterpenoids. These compounds exhibit diverse biological activities, including anticancer, anti-inflammatory, anti-microbial, and osteogenic effects, which are explored in this review. We summarize extraction techniques, structural properties, and recent findings on their pharmacological potential, offering a foundation for future research on therapeutic applications.
Method: The study focuses on retrieving articles from PubMed, Scopus, and Web of Science using the keyword “Croton tonkinensis”. The collected articles are analyzed to extract and summarize critical information related to the extraction processes, chemical structures, and biological activities of ent-kaurane diterpenoids isolated from Croton tonkinensis. Based on these findings, the research evaluates potential practical applications of these compounds and explores future research directions for Croton tonkinensis.
Results: Ent-kaurane diterpenoids extracted from Croton tonkinensis have emerged as a versatile class of bioactive compounds with significant therapeutic potential. Their extraction typically employs organic solvents such as methanol or ethanol, followed by chromatographic techniques for isolation and purification. Advanced analytical methods, including high-performance liquid chromatography and nuclear magnetic resonance spectroscopy, are crucial for elucidating their molecular structures. These diterpenoids exhibit notable biological activities across diverse therapeutic areas. As anticancer agents, they demonstrate potent efficacy in both monotherapy and combination therapies with radio- or chemotherapy, modulating key apoptotic and signaling pathways across various cancer types. Additionally, their strong anti-inflammatory properties, mediated by the regulation of nitric oxide production, oxidative stress, and NF-κB activation, underscore their potential in managing inflammatory diseases. With low IC₅₀ values and high efficacy in cell-based assays, these compounds also represent promising candidates for antimycobacterial therapies, particularly against drug-resistant tuberculosis. Furthermore, their osteogenic properties are evident in their ability to significantly enhance alkaline phosphatase (ALP) activity, upregulate osteoblastic gene promoter activity, and, in some cases, increase mRNA levels of ALP and collagen type I alpha, thus promoting osteoblast differentiation and bone matrix production. These findings highlight the therapeutic versatility of ent-kaurane diterpenoids, warranting further in vivo investigations to advance their clinical applications.
Conclusion: Ent-kaurane diterpenoids from Croton tonkinensis exhibit multifaceted biological activities, including anticancer, anti-inflammatory, antitubercular, and osteogenic effects. These findings highlight their potential as lead compounds for novel therapeutic agents.
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